Naturally occurring compound in Red Wine may be helpful in stopping progress of Alzheimer’s – Says StudyDaniel McCarthy (Author) Published Date : Sep 14, 2015 00:10 IST
A new drug in the investigational stages derived from a naturally occurring compound in foods like red grapes, dark chocolate, raspberries and certain red wines could stop the progression of Alzheimer s disease according to results obtained from clinical trials.
The compound resveratrol has also been credited earlier for the multiple health benefits it offers. Consequently, it was also suggested from some of the past studies that consuming a moderate quantity of red wine or eating dark chocolate constituted a healthy option.
In people who were diagnosed with mild/moderate Alzheimer s disease, a high dose of this compound, resveratrol was found to stabilize a biomarker that showed a decline with the progress of the disease.
Scott Turner, the principal investigator in the study from Georgetown University Medical Centre, Washington, DC, said that that the results were very interesting.
The study was carried out over two years between 2012 and 2014 and had 119 participants suffering from mild to moderate dementia on account of Alzheimer s. One group of the participants was given resveratrol treatment while a placebo was given to the others in the control group.
1 gram was also the highest dose of resveratrol tested, and this was administered twice daily by mouth. This was equivalent to what was found in nearly 1,000 bottles of red wine.
Over a period of 12 months, patients were treated with increased doses of resveratrol, and they showed little to no change in amyloid-beta 40 protein level in the blood and cerebrospinal fluid.
In contrast, the placebo group showed a decrease in the level of Albeta40 compared to their levels when the study began.
Turner explains that Albeta 40 tends to decrease with the worsening of dementia and the progress of Alzheimer s. It cannot be concluded from the present study that resveratrol treatment is beneficial. He added further that this was a single and small study where the findings called for further research to interpret the results accurately. He also added that it does, however, appear that the compound could penetrate the blood brain barrier, and that was an important observation.
The study has been published in journal Neurology, and further resveratrol was also found to be well tolerated and safe.
Naturally occurring compound in Red Wine may be helpful in stopping progress of Alzheimer’s – Says Study